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Exploring the <i>in-situ</i> evolution of Nitrofurantoin resistance in clinically derived Uropathogenic <i>Escherichia coli</i> isolates

2022-07-20

Abstract excerpt

<h4>BACKGROUND</h4> Nitrofurantoin has been re-introduced as a first-choice antibiotic to treat uncomplicated acute urinary tract infections in England and Wales. Its mode of action involves initial reduction by nitroreductases, to generate electrophilic intermediates that inhibit protein and nucleic acid synthesis. Highly effective against common uropathogens such as Escherichia coli , its use is accompanied by...

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Literature Corpus work
3554ea17-cd2a-58e1-9e93-051a09a9c476
DOI
10.1101/2022.07.19.500598
Open publication

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Exploring the <i>in-situ</i> evolution of Nitrofurantoin resistance in clinically derived Uropathogenic <i>Escherichia coli</i> isolatesDOI 10.1101/2022.07.19.500598
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