Article
Genetic and mass spectrometric tools for elucidating the physiological function(s) of cytochrome P450 enzymes from Mycobacterium tuberculosis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Ouellet Hugues, Chow Eric D, Guan Shenheng, Cox Jeffery S, Burlingame Alma L, de Montellano Paul R Ortiz
Abstract excerpt
Tuberculosis remains a leading cause of human mortality. The emergence of strains of Mycobacterium tuberculosis (Mtb), the causative agent, that are resistant to first- and second-line antitubercular drugs urges the development of new therapeutics. The genome of Mtb encodes 20 cytochrome P450 enzymes, at least some of which are potential candidates (CYP121, CYP125, and CYP128) for drug targeting. In this regard,...
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