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Structure–Function Analysis of the Essential Mycobacterium tuberculosis P450 Drug Target, CYP121A1

30 Apr 2024

Abstract excerpt

, the human pathogen that causes the deadly disease tuberculosis (TB). CYP121A1 is a unique P450 enzyme because it uses classical and non-classical P450 catalytic processes and has distinct structural features among P450s. However, a detailed investigation of CYP121A1 protein structures in terms of active site cavity dynamics and key amino acids interacting with bound ligands has yet to be undertaken. To address...

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PMID: 38732102
DOI: 10.3390/ijms25094886

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