Article

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

2021-08-20

Abstract excerpt

Induced pluripotent stem cells generated from patients with geographic atrophy as well as healthy individuals were differentiated to retinal pigment epithelium (RPE) cells. By integrating transcriptional profiles of 127,659 RPE cells generated from 43 individuals with geographic atrophy and 36 controls with genotype data, we identified 439 expression Quantitative Trait (eQTL) loci in cis that were associated with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee937868-afe4-5d6a-88bd-c224fd436a5c
DOI: 10.1101/2021.08.19.457044

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degenerationDOI 10.1101/2021.08.19.457044Read

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degenerationSemantic proximity Read

Patient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degeneration.Semantic proximity Read

Patient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degenerationSemantic proximity Read

A New Strategy to Identify and Annotate Human RPE-Specific Gene ExpressionSemantic proximity Read

An Integrated Multi-omics Single Cell Atlas of the Human RPE and ChoroidSemantic proximity Read

Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-SeqSemantic proximity Read

Translatomic response of retinal Müller glia to acute and chronic stressSemantic proximity Read

Genetic analyses of human fetal retinal pigment epithelium gene expression suggest ocular disease mechanismsSemantic proximity Read

Dynamic human retinal pigment epithelium (RPE) and choroid architecture based on single-cell transcriptomic landscape analysisSemantic proximity Read

Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular DegenerationSemantic proximity Read

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networksSemantic proximity Read

iPSC-derived retinal pigment epithelium: an in vitro platform to reproduce key cellular phenotypes and pathophysiology of retinal degenerative diseases.Semantic proximity Read