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Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

26 Jul 2022

Abstract excerpt

There are currently no treatments for geographic atrophy, the advanced form of age-related macular degeneration. Hence, innovative studies are needed to model this condition and prevent or delay its progression. Induced pluripotent stem cells generated from patients with geographic atrophy and healthy individuals were differentiated to retinal pigment epithelium. Integrating transcriptional profiles of 127,659...

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PMID: 35882847
DOI: 10.1038/s41467-022-31707-4

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