Article
Patient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degeneration.
Genome medicine - 10 May 2026
Hall Jenna C, Krishna Sudhakar Kavitha, Daniszewski Maciej, Senabouth Anne, Abbott Carla J, Liang Helena H, Kumar Himeesh, Lidgerwood Grace E, Mirzaei Mehdi, Ma Jessica Yw, Atkeson Trevor, Hirokawa Yumiko, Nandrot Emeline F, Barnett Alexander, Cazevieille Chantal, Manes Gaël, Mountford Simon, Thompson Philip, Fletcher Erica L, Wu Zhichao, Bahlo Melanie, Ansell Brendan R E, Paull Daniel, Hewitt Alex W, Guymer Robyn H, Powell Joseph E, Pébay Alice
Abstract excerpt
BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of vision loss. Reticular pseudodrusen (RPD), deposits on the apical side of the retinal pigment epithelium (RPE), signify a distinctive and critical AMD phenotype. Yet, their molecular basis and relationship to the conventional drusen seen in AMD remain unclear. METHODS: We generated induced pluripotent stem cell-derived RPE cells from a...
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