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Translatomic response of retinal Müller glia to acute and chronic stress

22 Nov 2022

Abstract excerpt

Analysis of retina cell type-specific epigenetic and transcriptomic signatures is crucial to understanding the pathophysiology of retinal degenerations such as age-related macular degeneration (AMD) and delineating cell autonomous and cell-non-autonomous mechanisms. We have discovered that Aldh1l1 is specifically expressed in the major macroglia of the retina, Müller glia, and, unlike the brain, is not expressed...

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PMID: 36423879
DOI: 10.1016/j.nbd.2022.105931

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