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Patient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degeneration

2025-11-24

Abstract excerpt

<h4>Background</h4> Age-related macular degeneration (AMD) is a leading cause of vision loss. Reticular pseudodrusen (RPD), deposits on the apical side of the retinal pigment epithelium (RPE), signify a distinctive and critical AMD phenotype. Yet, their molecular basis and relationship to the conventional drusen seen in AMD remain unclear. <h4>Results</h4> We generated induced pluripotent stem cell-derived RPE c...

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Literature Corpus work: 12a957ab-1c49-5eb0-b567-ddf71c75bb16
DOI: 10.1101/2025.11.19.689393

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