Article

Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer

2023-09-16

Abstract excerpt

<h4>SUMMARY</h4> Nuclear speckles are membrane-less bodies within the cell nucleus enriched in RNA biogenesis, processing, and export factors. In this study we investigated speckle phenotype variation in human cancer, finding a reproducible speckle signature, based on RNA expression of speckle-resident proteins, across >20 cancer types. Of these, clear cell renal cell carcinoma (ccRCC) exhibited a clear correlati...

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Literature Corpus work: ee724987-387c-59c5-a844-30f980bdb8df
DOI: 10.1101/2023.09.14.557228

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