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Spatial Functional Mapping of Hypoxia Inducible Factor Heterodimerisation and Immune checkpoint regulators in clear cell Renal Cell Carcinoma

2023-09-20

Abstract excerpt

<h4>Background: </h4> Clear cell renal cell carcinoma (ccRCC) is a highly malignant subtype of kidney cancer. 90% of ccRCC have inactivating mutations of VHL that stablise transcription factors, HIF1α and HIF2α, only stabilised in hypoxia. The varied response to HIF2 inhibition, in the preclinical and clinical settings, suggests that assessment of HIF2αactivation state, not just expression levels is required as a...

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Literature Corpus work
0866d9ca-27b9-52c6-99d1-0d03049ef428
DOI
10.21203/rs.3.rs-3335278/v1
Open publication

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Spatial Functional Mapping of Hypoxia Inducible Factor Heterodimerisation and Immune checkpoint regulators in clear cell Renal Cell CarcinomaDOI 10.21203/rs.3.rs-3335278/v1
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