Article

Chitotriosidase, a biomarker of Amyotrophic Lateral Sclerosis accentuates neurodegeneration in spinal motor neurons through neuroinflammation.

2020-06-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Cerebrospinal fluid from Amyotrophic Lateral Sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models. Search for identification of toxic factor(s) in CSF revealed an enhancement in the level and enzyme activity of chitotriosidase (CHIT-1). Here, we have investigated its upregulation in a large cohort of...

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Literature Corpus work: ee6f1f13-f334-5009-8b63-65668eeb3d3e
DOI: 10.21203/rs.2.21147/v2

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