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Chitotriosidase as biomarker for early stage amyotrophic lateral sclerosis: a multicenter study

12 Feb 2021

Abstract excerpt

Objective: Levels of chitotriosidase (CHIT1) are increased in the cerebrospinal fluid (CSF) of amyotrophic lateral sclerosis (ALS) patients reflecting microglial activation. Here, we determine the diagnostic and prognostic potential of CHIT1 for early symptomatic ALS. Methods: Overall, 275 patients from 8 European neurological centers were examined. We included ALS with <6 and >6 months from symptom onset, other...

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PMID: 33576252
DOI: 10.1080/21678421.2020.1861023

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