Article

Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex

2020-09-03

Abstract excerpt

Angiotensin converting enzyme 2 (ACE2) is a key regulator of the renin-angiotensin system, but also the functional receptor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on structural similarity with other γ-secretase (γS) targets, we hypothesized that ACE2 may be affected by γS proteolytic activity. We found that after ectodomain shedding, ACE2 is targeted for intramembrane proteolysi...

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Literature Corpus work: ee2d273d-2e32-50d0-9b9b-3535fd5af777
DOI: 10.1101/2020.09.01.277954

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