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Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2

23 Dec 2022

Abstract excerpt

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2. The full-length membrane form of ACE2 (memACE2) undergoes ectodomain shedding to generate a shed soluble form (solACE2) that mediates SARS-CoV-2 entry via receptor-mediated endocytosis. Currently, it is not known how the physiological...

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PMID: 36564389
DOI: 10.1038/s41467-022-35590-x

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