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Article

TMPRSS2 regulates ACE2 trafficking and shedding

2026-06-18

Abstract excerpt

Angiotensin-converting enzyme 2 (ACE2) functions as the receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus utilizes the cellular endocytic machinery for entry by binding to defined residues on ACE2 with its spike protein (S protein), whose activation requires a priming process by another transmembrane protease, the transmembrane protease serine 2 (TMPRSS2). In addition, ACE2 i...

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Literature Corpus work
0e15a76b-34e1-5978-b55a-9c964517729e
DOI
10.64898/2026.06.17.732908
Open publication

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