Article

Differential Ability of S Protein of SARS-CoV-2 Variants to Downregulate ACE2

2023-12-15

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of corona-virus disease 19 (COVID-19) and employs angiotensin-converting enzyme 2 (ACE2) as the recep-tor. Although the expression of ACE2 is crucial for cellular entry, we found that the interaction of ACE2 with the Spike (S) protein in the same cells led to its downregulation through degradation in the lysosomal compartment via t...

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Literature Corpus work: 24b940c8-2162-5a38-aa75-2eb224807ddd
DOI: 10.20944/preprints202312.1139.v1

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