Sirtuins and Resveratrol in Cardiorenal Diseases: A Narrative Review of Mechanisms and Therapeutic Potential

Abstract excerpt

Aging is a very complex process and it has been linked with Sirtuins. Sirtuin enzymes are a family of deacetylases that are related with caloric restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Up to now, seven sirtuins have been recognized. Our purpose is to clarify the role of sirtuins in Chronic Kidney Disease (CKD). Moreover, as heart and kidney diseases are stric...

Topics

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• Adenosine and Purinergic Signaling
• Adipose Tissue and Metabolism
• Autophagy in Disease and Therapy
• Biochemical effects in animals
• Calcium signaling and nucleotide metabolism
• Endoplasmic Reticulum Stress and Disease
• PARP inhibition in cancer therapy
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

ee240ecd-3331-5374-8ac2-601a0fa7441f

DOI

10.20944/preprints202503.1085.v1