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The Role of Sirtuins in Kidney Diseases

12 Sept 2020

Abstract excerpt

Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals have seven different sirtuins, SIRT1-7, and the diverse biological functions of each sirtuin are due to differences in...

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PMID: 32932720
DOI: 10.3390/ijms21186686

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