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Article

Emerging beneficial roles of sirtuins in heart failure

24 May 2012

Abstract excerpt

Sirtuins are a highly conserved family of histone/protein deacetylases whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. In mammalian cells, seven sirtuins (SIRT1-7) modulate distinct metabolic and stress-response pathways, SIRT1 and SIRT3 having been most extensively investigated in the cardiovascular system. SIRT1 and SIRT3 are mainly located in the nuclei and...

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PMID: 22622703
DOI: 10.1007/s00395-012-0273-5

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