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Sirtuin 3 in renal diseases and aging: From mechanisms to potential therapies

23 Jun 2024

Abstract excerpt

)-dependent deacetylases. In mammals, SIRTs comprise seven members (SIRT1-7) which are localized to different subcellular compartments. As the most prominent mitochondrial deacetylases, SIRT3 is known to be regulated by various mechanisms and participate in virtually all aspects of mitochondrial homeostasis and metabolism, exerting significant impact on multiple organs. Notably, the kidneys possess an abundance...

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PMID: 38917912
DOI: 10.1016/j.phrs.2024.107261

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