Article

Characterization and optimization of neurosphere culture as in vitro screening tool against valproic acid-induced neurodevelopmental toxicity

2025-07-10

Abstract excerpt

<title>Abstract</title> <p>Valproic acid (VPA) is an antiepileptic drug known to cause autism when consumed during pregnancy. Autism is a complex neurodevelopmental disorder of early-onset, highly variable in its clinical presentation. In spite of well validated animal model for autism, screening compounds is time consuming, laborious and challenging. In utero VPA exposure in rodents leads to autism-like behavior...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee21ddac-1672-5c06-9743-152896e5ad73
DOI: 10.21203/rs.3.rs-6809301/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization and optimization of neurosphere culture as in vitro screening tool against valproic acid-induced neurodevelopmental toxicityDOI 10.21203/rs.3.rs-6809301/v1Read

Differential Neurodevelopmental Disruption by Bisphenol A (BPA) and Valproic Acid (VPA) in Human Forebrain OrganoidsSemantic proximity Read

Rapid effects of valproic acid on the fetal brain transcriptome: Implications for brain development and autismSemantic proximity Read

In utero Exposure to Valproic Acid throughout Pregnancy Causes Phenotypes of Autism in Offspring Mice.Semantic proximity Read

Robust and reproducible neuronal differentiation of human embryonic stem cells for neurotoxicologySemantic proximity Read

Dynamic culture of cerebral organoids using a pillar/perfusion plate for the assessment of developmental neurotoxicitySemantic proximity Read

Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoidsSemantic proximity Read

Intranasal Delivery of Hypoxia-Primed Wharton’s Jelly MSC-Derived sEVs Reprograms Neuroimmune Signalling and Ameliorates Behavioural Deficits in a Valproic Acid–Induced Mouse Model of Autism Spectrum DisorderSemantic proximity Read

Cerebral organoids as an in vitro model to study autism spectrum disorders.Semantic proximity Read

Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primatesSemantic proximity Read

Effects of valproic acid on gene expression during human embryonic stem cell differentiation into neuronsSemantic proximity Read

Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development.Semantic proximity Read