Article

Rapid effects of valproic acid on the fetal brain transcriptome: Implications for brain development and autism

2023-05-02

Abstract excerpt

<h4>ABSTRACT</h4> There is an increased incidence of autism among the children of women who take the anti-epileptic, mood stabilizing drug, valproic acid (VPA) during pregnancy; moreover, exposure to VPA in utero causes autistic-like symptoms in rodents and non-human primates. Analysis of RNA-seq data obtained from E12.5 fetal mouse brains 3 hours after VPA administration revealed that VPA significantly increase...

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Literature Corpus work: efdd9cb6-c1c8-5370-9daa-7179c37d40dd
DOI: 10.1101/2023.05.01.538959

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