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Article

Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development.

PloS one - 1 Jan 2013

Hill Eric J, Nagel David A, O'Neil John D, Torr Elizabeth, Woehrling Elizabeth K, Devitt Andrew, Coleman Michael D

Abstract excerpt

Mood stabilising drugs such as lithium (LiCl) and valproic acid (VPA) are the first line agents for treating conditions such as Bipolar disorder and Epilepsy. However, these drugs have potential developmental effects that are not fully understood. This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene...

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Identifiers

PMID: 23527032
DOI: 10.1371/journal.pone.0058822
PMCID: PMC3602582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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