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Effects of valproic acid on gene expression during human embryonic stem cell differentiation into neurons

1 Jan 2014

Abstract excerpt

The widely used antiepileptic drug valproic acid (VPA) is known to exhibit teratogenicity in the form of a failure of the neural tube in humans. Embryonic stem cells (ESCs) are reported to be a promising cell source for evaluating chemical teratogenicity, because they are capable of reproducing embryonic developmental model and enable reduction in the number of experimental animals used. We previously...

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PMID: 24849673
DOI: 10.2131/jts.39.383

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