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Intranasal Delivery of Hypoxia-Primed Wharton’s Jelly MSC-Derived sEVs Reprograms Neuroimmune Signalling and Ameliorates Behavioural Deficits in a Valproic Acid–Induced Mouse Model of Autism Spectrum Disorder

2026-05-27

Abstract excerpt

<h4>Background</h4> Beyond disrupted neurodevelopment, autism spectrum disorder (ASD) encompasses progressive neurodegenerative alterations that remain refractory to standard of care behavioral therapies, highlighting the need for biologically targeted adjunctive interventions. Although, Mesenchymal stem cell (MSC) derived small extracellular vesicles (sEVs) have emerged as potent neuroprotective agents; however,...

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Literature Corpus work: b6496d09-68fe-517e-a4ca-c053b195e00e
DOI: 10.64898/2026.05.24.721255

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