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Multivariate association between single-nucleotide polymorphisms in Alzgene linkage regions and structural changes in the brain: discovery, refinement and validation

2016-11-17

Abstract excerpt

Both genetic variants and brain region abnormalities are recognized to play a role in cognitive decline. We explore the association between singlenucleotide polymorphisms (SNPs) in linkage regions for Alzheimer’s disease and rates of decline in brain structure using data from the Alzheimers Disease Neuroimaging Initiative (ADNI). In an initial discovery stage, we assessed the presence of linear association between...

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Literature Corpus work
ee1cf9ea-cb01-5cd4-81ee-d666f931f95f
DOI
10.1101/088310
Open publication

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Multivariate association between single-nucleotide polymorphisms in Alzgene linkage regions and structural changes in the brain: discovery, refinement and validationDOI 10.1101/088310
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