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Article

Identification of gene pathways implicated in Alzheimer's disease using longitudinal imaging phenotypes with sparse regression.

NeuroImage - 15 Nov 2012

Silver Matt, Janousova Eva, Hua Xue, Thompson Paul M, Montana Giovanni

Abstract excerpt

We present a new method for the detection of gene pathways associated with a multivariate quantitative trait, and use it to identify causal pathways associated with an imaging endophenotype characteristic of longitudinal structural change in the brains of patients with Alzheimer's disease (AD). Our method, known as pathways sparse reduced-rank regression (PsRRR), uses group lasso penalised regression to jointly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22982105
DOI: 10.1016/j.neuroimage.2012.08.002
PMCID: PMC3549495

Genes

ACACA
ACTN1
ADCY2
APOE
GNAI1
TOMM40

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