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Article

Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer's Disease.

Scientific reports - 14 Mar 2017

Hao Xiaoke, Li Chanxiu, Du Lei, Yao Xiaohui, Yan Jingwen, Risacher Shannon L, Saykin Andrew J, Shen Li, Zhang Daoqiang

Abstract excerpt

Neuroimaging genetics is an emerging field that aims to identify the associations between genetic variants (e.g., single nucleotide polymorphisms (SNPs)) and quantitative traits (QTs) such as brain imaging phenotypes. In recent studies, in order to detect complex multi-SNP-multi-QT associations, bi-multivariate techniques such as various structured sparse canonical correlation analysis (SCCA) algorithms have been...

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PMID: 28291242
DOI: 10.1038/srep44272
PMCID: PMC5349597

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