Article

Machine learning suggests polygenic contribution to cognitive dysfunction in amyotrophic lateral sclerosis

2019-12-27

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a multi-system disease characterized primarily by progressive muscle weakness. Cognitive dysfunction is commonly observed in patients, however factors influencing risk for cognitive dysfunction remain elusive. Using sparse canonical correlation analysis (sCCA), an unsupervised machine-learning technique, we observed that single nucleotide polymorphisms collectively associate...

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Literature Corpus work: 38f31a52-84c3-520c-8a3b-f57be9d2e8b8
DOI: 10.1101/2019.12.23.19014407

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