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Article

Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus.

The Journal of clinical investigation - 1 Aug 2007

Wu Tianfu, Qin Xiangmei, Kurepa Zoran, Kumar Kirthi Raman, Liu Kui, Kanta Hasna, Zhou Xin J, Satterthwaite Anne B, Davis Laurie S, Mohan Chandra

Abstract excerpt

Though B cells play key roles in lupus pathogenesis, the molecular circuitry and its dysregulation in these cells as disease evolves remain poorly understood. To address this, a comprehensive scan of multiple signaling axes using multiplexed Western blotting was undertaken in several different murine lupus strains. PI3K/AKT/mTOR (mTOR, mammalian target of rapamycin), MEK1/Erk1/2, p38, NF-kappaB, multiple Bcl-2...

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Identifiers

PMID: 17641780
DOI: 10.1172/JCI30398
PMCID: PMC1913486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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