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Article

The immunobiology of mTOR in autoimmunity.

Journal of autoimmunity - 1 Jun 2020

Suto Takahito, Karonitsch Thomas

Abstract excerpt

The mechanistic target of rapamycin (mTOR) is a master regulator of the inflammatory response in immune and non-immune cells. In immune cells mTOR regulates metabolism to fuel cell fate decision, proliferation and effector functions. In non-immune cells, such as fibroblast, it controls inflammation-associated proliferation and migration/invasion, shapes the expression of cytokines and chemokines and promotes...

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Identifiers

PMID: 31831256
DOI: 10.1016/j.jaut.2019.102373

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