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Article

Modulation of TSC-mTOR signaling on immune cells in immunity and autoimmunity

1 Jun 2013

Abstract excerpt

The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase which has a central role in the regulation of cell growth and metabolism. In the study of the mTOR signaling pathway, tuberous sclerosis complex (TSC) 1/2 complex is identified as a critical regulator of mTOR activity. TSC1/2 plays important roles for immune cell homeostasis and differentiation by negative control of...

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PMID: 23804073
DOI: 10.1002/jcp.24426

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