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Article

mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome

28 Nov 2022

Abstract excerpt

Still's disease is a severe inflammatory syndrome characterized by fever, skin rash and arthritis affecting children and adults. Patients with Still's disease may also develop macrophage activation syndrome, a potentially fatal complication of immune dysregulation resulting in cytokine storm. Here we show that mTORC1 (mechanistic target of rapamycin complex 1) underpins the pathology of Still's disease and...

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PMID: 36443301
DOI: 10.1038/s41467-022-34480-6

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