Article

Gene expression from unintegrated HIV-1 is restricted by the SMC5/6 complex

2020-01-01

Abstract excerpt

Integration of viral DNA into the host genome is the hallmark of human immunodeficiency virus 1 (HIV-1) infections. However, in early infection, the most abundant viral DNA species are extrachromosomal unintegrated viral genomes, which despite being competent for gene expression, are poorly expressed in the host cell. This suggests the existence of a restriction mechanism acting selectively on extrachromosomal DNA...

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Literature Corpus work: ee06b359-6598-55ec-acbc-b7190167f9a5
DOI: 10.17863/cam.65134

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