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Article

The Restriction Factors of Human Immunodeficiency Virus

6 Oct 2012

Abstract excerpt

Cellular proteins called "restriction factors" can serve as powerful blockades to HIV replication, but the virus possesses elaborate strategies to circumvent these barriers. First, we discuss general hallmarks of a restriction factor. Second, we review how the viral Vif protein protects the viral genome from lethal levels of cDNA deamination by promoting APOBEC3 protein degradation; how the viral Vpu, Env, and...

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PMID: 23043100
DOI: 10.1074/jbc.r112.416925

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