Article

Bloom syndrome helicase is required for efficient HIV-1 reverse transcription in macrophages

2026-04-27

Abstract excerpt

The induction of DNA damage by HIV-1 prior to integration suggests a function for DNA damage responses (DDR) during early infection, however what this role is remains incompletely understood. Initial experiments, using specific inhibitors for DDR pathways demonstrate that both ATM and ATR are necessary for efficient HIV-1 infection of macrophages with ATM acting at the late reverse transcription step. To identify...

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Literature Corpus work: 56c8af37-3e2d-546b-a2d7-1a3b7cc88ce5
DOI: 10.64898/2026.04.26.720894

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