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Article

Comprehensive off-target analysis of dCas9-SAM-mediated HIV reactivation via long noncoding RNA and mRNA profiling.

BMC medical genomics - 10 Sept 2018

Zhang Yonggang, Arango Gustavo, Li Fang, Xiao Xiao, Putatunda Raj, Yu Jun, Yang Xiao-Feng, Wang Hong, Watson Layne T, Zhang Liqing, Hu Wenhui

Abstract excerpt

BACKGROUND: CRISPR/CAS9 (epi)genome editing revolutionized the field of gene and cell therapy. Our previous study demonstrated that a rapid and robust reactivation of the HIV latent reservoir by a catalytically-deficient Cas9 (dCas9)-synergistic activation mediator (SAM) via HIV long terminal repeat (LTR)-specific MS2-mediated single guide RNAs (msgRNAs) directly induces cellular suicide without additional...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 30200981
DOI: 10.1186/s12920-018-0394-2
PMCID: PMC6131778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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