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Elimination of infectious HIV DNA by CRISPR–Cas9

23 Aug 2019

Abstract excerpt

Current antiretroviral drugs can efficiently block HIV replication and prevent transmission, but do not target the HIV provirus residing in cells that constitute the viral reservoir. Because drug therapy interruption will cause viral rebound from this reservoir, HIV-infected individuals face lifelong treatment. Therefore, novel therapeutic strategies are being investigated that aim to permanently inactivate the...

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PMID: 31450074
DOI: 10.1016/j.coviro.2019.07.001

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