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Article

Reconstituted depolarization-induced Ca <sup>2+</sup> release platform for skeletal muscle disease mutation validation and drug discovery

2022-07-02

Abstract excerpt

In skeletal muscle excitation-contraction (E-C) coupling, depolarization of the plasma membrane triggers Ca 2+ release from the sarcoplasmic reticulum (SR), referred to as depolarization-induced Ca 2+ release (DICR). DICR occurs via the type 1 ryanodine receptor (RyR1), which physically interacts with the dihydropyridine receptor Cav1.1 subunit in specific machinery formed with additional essential components in...

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Literature Corpus work
edf8b724-d093-5ac7-b940-5d6ffc618ac8
DOI
10.1101/2022.06.29.498090
Open publication

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Reconstituted depolarization-induced Ca <sup>2+</sup> release platform for skeletal muscle disease mutation validation and drug discoveryDOI 10.1101/2022.06.29.498090
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