Article
Ryanodine receptor channelopathies.
Biochemical and biophysical research communications - 1 Oct 2004
Benkusky Nancy A, Farrell Emily F, Valdivia Héctor H
Abstract excerpt
Ryanodine receptors (RyR) are the Ca2+ release channels of sarcoplasmic reticulum that provide the majority of the [Ca2+] necessary to induce contraction of cardiac and skeletal muscle cells. In their cellular environment, RyRs are exquisitely regulated by a variety of cytosolic factors and accessory proteins so that their output signal (Ca2+) induces cell contraction without igniting signaling pathways that...
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