Article
Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulum.
Biochimica et biophysica acta - 1 May 2011
Maclennan David H, Zvaritch Elena
Abstract excerpt
This review focuses on muscle disorders and diseases caused by defects in the Ca(2+) release channels of the sarcoplasmic reticulum, the ryanodine receptors, and in the luminal, low affinity, high capacity Ca(2+)-binding proteins, calsequestrins. It provides a time line over the past half century of the highlights of research on malignant hyperthermia (MH), central core disease (CCD) and catecholaminergic...
Topics
- Animals
- Calcium Signaling
- Humans
- Models, Biological
- Muscular Diseases
- Mutation
- Penetrance
- Sarcoplasmic Reticulum
