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Article

A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery.

The Journal of general physiology - 5 Dec 2022

Murayama Takashi, Kurebayashi Nagomi, Numaga-Tomita Takuro, Kobayashi Takuya, Okazaki Satoru, Yamashiro Kyosuke, Nakada Tsutomu, Mori Shuichi, Ishida Ryosuke, Kagechika Hiroyuki, Yamada Mitsuhiko, Sakurai Takashi

Abstract excerpt

In skeletal muscle excitation-contraction (E-C) coupling, depolarization of the plasma membrane triggers Ca2+ release from the sarcoplasmic reticulum (SR), referred to as depolarization-induced Ca2+ release (DICR). DICR occurs through the type 1 ryanodine receptor (RyR1), which physically interacts with the dihydropyridine receptor Cav1.1 subunit in specific machinery formed with additional essential components...

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Source

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Identifiers

PMID: 36318155
DOI: 10.1085/jgp.202213230
PMCID: PMC9629852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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