Article

Single-cell RNA Sequencing Defines Prognostic Subtypes and Identifies AIF1L as a Therapeutic Target in Colorectal Cancer

2025-08-17

Abstract excerpt

<title>Abstract</title> <p>Colorectal cancer (CRC) progression and therapy resistance are driven by heterogeneous tumor cell populations and microenvironmental interactions. However, a comprehensive single-cell atlas across patients that captures this heterogeneity, and its clinical implications has been lacking. Such an atlas could reveal rare tumor subpopulations that underpin disease aggressiveness and offer n...

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Literature Corpus work: 2dd6c065-686d-50f3-b7a7-a9462ea528c2
DOI: 10.21203/rs.3.rs-7271791/v1

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