Article

Polygenic transcriptome risk scores enhance predictive accuracy in atopic dermatitis

2025-01-07

Abstract excerpt

<h4>Background</h4> Incorporation of gene expression when estimating polygenic risk scores (PRS) in atopic dermatitis (AD) may provide additional insights in disease pathogenesis and enhance predictive accuracy. <h4>Objective</h4> In this study, we developed polygenic transcriptome risk scores (PTRSs) derived from AD-enriched tissues and evaluated their performance against traditional PRS models and a baseline ris...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: edc4f7a1-ee82-5a5b-ab28-cf37565ba031
DOI: 10.1101/2025.01.07.25320097

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic transcriptome risk scores enhance predictive accuracy in atopic dermatitisDOI 10.1101/2025.01.07.25320097Read

Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors.Semantic proximity Read

Meta-analysis of atopic dermatitis in 1,094,060 individuals identifies new risk loci, and sub-analysis characterizes the loci with disease severity and onsetSemantic proximity Read

Identifying Atopic Dermatitis Risk Loci in 1,094,060 Individuals with Subanalysis of Disease Severity and Onset.Semantic proximity Read

Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores.Semantic proximity Read

Multitissue Integrative Analysis Identifies Susceptibility Genes for Atopic Dermatitis.Semantic proximity Read

Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis.Semantic proximity Read

Multi-omic triangulation identifies molecular candidates of atopic dermatitis severitySemantic proximity Read

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries.Semantic proximity Read

Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction.Semantic proximity Read

Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis.Semantic proximity Read

Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk ScoresSemantic proximity Read

Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk ScoresSemantic proximity Read