Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors.

doi:10.1016/j.jaci.2021.05.034

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Article

Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors.

The Journal of allergy and clinical immunology - 1 Jan 2022

Arehart Christopher H, Daya Michelle, Campbell Monica, Boorgula Meher Preethi, Rafaels Nicholas, Chavan Sameer, David Gloria, Hanifin Jon, Slifka Mark K, Gallo Richard L, Hata Tissa, Schneider Lynda C, Paller Amy S, Ong Peck Y, Spergel Jonathan M, Guttman-Yassky Emma, Leung Donald Y M, Beck Lisa A, Gignoux Christopher R, Mathias Rasika A, Barnes Kathleen C

Abstract excerpt

BACKGROUND: While numerous genetic loci associated with atopic dermatitis (AD) have been discovered, to date, work leveraging the combined burden of AD risk variants across the genome to predict disease risk has been limited. OBJECTIVES: This study aims to determine whether polygenic risk scores (PRSs) relying on genetic determinants for AD provide useful predictions for disease occurrence and severity. It also...

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Identifiers

PMID: 34111454
DOI: 10.1016/j.jaci.2021.05.034
PMCID: PMC8973457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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