Article
Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis.
Nature communications - 2 Oct 2023
Sekita Aiko, Kawasaki Hiroshi, Fukushima-Nomura Ayano, Yashiro Kiyoshi, Tanese Keiji, Toshima Susumu, Ashizaki Koichi, Miyai Tomohiro, Yazaki Junshi, Kobayashi Atsuo, Namba Shinichi, Naito Tatsuhiko, Wang Qingbo S, Kawakami Eiryo, Seita Jun, Ohara Osamu, Sakurada Kazuhiro, Okada Yukinori, Amagai Masayuki, Koseki Haruhiko
Abstract excerpt
Atopic dermatitis (AD) is a skin disease that is heterogeneous both in terms of clinical manifestations and molecular profiles. It is increasingly recognized that AD is a systemic rather than a local disease and should be assessed in the context of whole-body pathophysiology. Here we show, via integrated RNA-sequencing of skin tissue and peripheral blood mononuclear cell (PBMC) samples along with clinical data...
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