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Article

Polygenic transcriptome risk scores enhance predictive accuracy in atopic dermatitis.

Journal of translational medicine - 23 May 2025

Antonatos Charalabos, Budu-Aggrey Ashley, Pontikas Alexandros, Akritidis Adam, Pasmatzi Efstathia, Tsiogka Aikaterini, Gregoriou Stamatis, Grafanaki Katerina, Paternoster Lavinia, Vasilopoulos Yiannis

Abstract excerpt

BACKGROUND: Incorporation of gene expression when estimating polygenic risk scores (PRS) in atopic dermatitis (AD) may provide additional insights in disease pathogenesis and enhance predictive accuracy. In this study, we developed polygenic transcriptome risk scores (PTRSs) derived from AD-enriched tissues and evaluated their performance against traditional PRS models and a baseline risk model incorporating...

Read the complete abstract on PubMed

Topics

Humans
Dermatitis, Atopic
Transcriptome
Multifactorial Inheritance
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Female

Male

Middle Aged

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 40410830
DOI: 10.1186/s12967-025-06570-8
PMCID: PMC12102998

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