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Potentiating Na <sub>V</sub> 1.1 in Dravet syndrome patient iPSC-derived GABAergic neurons increases neuronal firing frequency and decreases network synchrony

2023-09-29

Abstract excerpt

Dravet syndrome is a developmental and epileptic encephalopathy characterized by seizures, behavioral abnormalities, developmental deficits, and elevated risk of sudden unexpected death in epilepsy (SUDEP). Most patient cases are caused by de novo loss-of-function mutations in the gene SCN1A , causing a haploinsufficiency of the alpha subunit of the voltage-gated sodium channel Na V 1.1. Within the brain, Na V...

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Literature Corpus work
0a59262f-c21f-59dc-a0f8-bd4f06713689
DOI
10.1101/2023.09.28.559990
Open publication

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Potentiating Na <sub>V</sub> 1.1 in Dravet syndrome patient iPSC-derived GABAergic neurons increases neuronal firing frequency and decreases network synchronyDOI 10.1101/2023.09.28.559990
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