Article

Hypersynchronous iPSC-derived <i>SHANK2</i> neuronal networks are rescued by mGluR5 agonism

2024-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Variants in the gene encoding the postsynaptic scaffolding protein SHANK2 are associated with several neurodevelopmental disorders, including autism spectrum disorder. Here, we used in vitro multielectrode arrays and pharmacological manipulations to characterize how functional connectivity and network-level firing properties were altered in cultures of human iPSC-derived SHANK2 neurons. Using...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 280b0bb2-3839-5653-b53f-f198f657bc30
DOI: 10.1101/2024.07.30.605451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypersynchronous iPSC-derived <i>SHANK2</i> neuronal networks are rescued by mGluR5 agonismDOI 10.1101/2024.07.30.605451Read

Hyperexcitability in human <i>MECP2</i> null neuronal networks manifests as calcium-dependent reverberating super burstsSemantic proximity Read

"SHANK3 deficiency alters early progenitor dynamics and reveals shared pathways with neurodegeneration".Semantic proximity Read

Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.Semantic proximity Read

L-type voltage-gated calcium channel regulation of <i>in vitro</i> human cortical neuronal networksSemantic proximity Read

Autism-associated Shank3 is essential for homeostatic plasticity and neuronal circuit stabilitySemantic proximity Read

Identification of neural oscillations and epileptiform changes in human brain organoidsSemantic proximity Read

Neuronal network dysfunction in a human model for Kleefstra syndrome mediated by enhanced NMDAR signalingSemantic proximity Read

Potentiating Na <sub>V</sub> 1.1 in Dravet syndrome patient iPSC-derived GABAergic neurons increases neuronal firing frequency and decreases network synchronySemantic proximity Read

Data-driven burst shape analysis for functional phenotyping of neuronal culturesSemantic proximity Read

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical OrganoidsSemantic proximity Read

<i>CACNA1A</i> haploinsufficiency leads to reduced synaptic function and increased intrinsic excitabilitySemantic proximity Read

Cerebral Organoids Uncover Mechanisms of Neural Activity Changes in EpileptogenesisSemantic proximity Read