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Article

Mechanistic insights into the phosphatidylinositol binding properties of the pleckstrin homology domain of lamellipodin.

Molecular bioSystems - 1 Mar 2016

Gorai Sukhamoy, Paul Debasish, Haloi Nandan, Borah Rituparna, Santra Manas Kumar, Manna Debasis

Abstract excerpt

Lamellipodin (Lpd) protein plays an important role in the formation of lamellipodial protrusion which is crucial in actin dynamics, cell polarity and motility. Lpd promotes actin polymerization with the help of members of the Ena/VASP family of actin regulators and tethering them to actin filaments. It is well documented that Lpd protein interacts with the membrane containing phosphatidylinositols through its...

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Identifiers

PMID: 26726010
DOI: 10.1039/c5mb00731c

Genes

PIP
SPR
VASP

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